ADVANCEMENTS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES FOR GENETIC ANALYSIS

Abstract

Next-generation sequencing (NGS) technologies have emerged as powerful tools for analysis of DNA and RNA sequences. NGS platforms can generate millions of sequences in parallel, producing vast amounts of biological data. Recent advances in NGS technologies and applications for genomic analysis are discussed. Next-generation sequencing (NGS) technologies have revolutionized genomic research by enabling rapid, high-throughput sequencing of DNA and RNA at significantly reduced cost. NGS platforms can generate millions of sequences in parallel, producing vast amounts of biological data (Shekhar Pareek et al., 2011). NGS technologies have opened new avenues in basic research and numerous practical applications in agriculture, diagnostics, forensics, biomedicine, and other fields. This chapter reviews recent advances in NGS technologies and discusses different applications of NGS in genomic research, including de novo sequencing, comparative sequencing, resequencing, transcriptome analysis, and epigenomics. Next-generation sequencing (NGS) technologies have emerged as powerful tools for analysis of DNA and RNA sequences (Shekhar Pareek et al., 2011). NGS platforms can generate millions of sequences in parallel, producing vast amounts of biological data. This chapter briefly introduces NGS technologies and principles, reviews recent advances in NGS technologies, and discusses applications of NGS in genomic research.