ACUTE LEUKEMIA BEFORE AND AFTER CHEMOTHERAPY WITH RESPECT TO LIVER FUNCTION TESTS

Authors

  • Moath Hassan Aljowyyan, Athil Abdulaziz Almesned, Isra Ali Alsohaibani, Basmah algarbi, Nawal Ali Aleisawi Author

Abstract

Background: Chemotherapeutic agents can cause hypersensitivity reactions or direct hepatic toxicity, while altered liver function can change drug metabolism and increase the risk of non-hepatic toxicity.

Methodology: Serum total bilirubin was measured with the DMSO method, while serum AST and ALT were measured using the kinetic method before and after chemotherapy doses.

Results: The results found that chemotherapy-induced hepatotoxicity in patients with acute leukaemia.

Conclusions: This study concluded that chemotherapeutic drugs cause an increase in serum total bilirubin, ALT, and AST during the treatment of acute leukaemia. Liver function tests should be performed on a regular basis while treating leukaemia patients.

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Published

2024-05-20

Issue

Vol. 6 No. 1 (2024)

Section

Articles