CONTEMPLATIVE STUDY OF RISK FACTORS ASSOCIATED WITH VASCULAR ENDOTHELIAL DYSFUNCTION

Abstract

Endothelial Dysfunction is a condition in which the Endothelium adverse effects are seen and there is disarray of poise homeostasis due to Endothelium on vascular tree leading to severe vasoconstriction ascribed to increased presence of vasoconstrictive autacoids. There are copious pivotal risk factors associated in pathobiology of vascular endothelium dysfunction. The pathogenesis of vascular endothelial Dysfunction is multi-factorial and the pinpoint mechanisms is still ambiguous . In current review, various risk factors associated with vascular endothelial Dysfunction in terms of development and progression have been discussed.  The study summarize that Oxidative stress, TGF beta, TNF alpha, renin angiotensin aldosterone system and Protein kinase C are closely associated with vascular endothelial dysfunction. There are limited therapeutic interventions available in the market, among all statins are observed to be the standard drug so far for management of the disease.